Functional Medicine w/ Leah O’Connor – Foundational Nutrition: Building Health from the Inside Out

Functional Medicine with Leah O'Connor

In functional medicine, we believe that optimal health starts with giving the body what it needs to thrive—starting at the cellular level. Foundational nutrition is exactly that: the base upon which resilient health is built. While an individualized approach is key, there are a few core nutrients that support almost every system in the body. These essentials act as nutritional insurance in our modern world, where even a clean diet may fall short due to soil depletion, stress, and environmental toxins.

Here are five foundational supplements we often recommend to restore balance and support long-term vitality:

1. High-Quality Multivitamin

Good nutrition is essential for health, while micronutrient deficiencies can contribute to chronic disease. Yet many people underestimate the importance of meeting daily nutrient needs. The body requires a wide range of vitamins and minerals to support energy production, immune function, detoxification, hormone balance, and tissue repair.

Even a single nutrient deficiency can disrupt critical metabolic processes. Studies by the USDA show that the average American diet is low in essential micronutrients. Factors like soil depletion, food processing, and long storage times reduce nutrient content. As a result, many Americans fail to meet the recommended daily intake, increasing their risk for long-term health issues.

2. Omega-3 Fish Oil (EPA/DHA)

Omega-3 fatty acids are vital nutrients that play a foundational role in human health. Called “essential” because the body cannot produce them on its own, they must be obtained through diet or supplementation. Fish oil supports a wide range of biological functions from healthy circulation and brain development to immune regulation and joint mobility. They are key structural components of tissues throughout the body, including the heart, eyes, skin, and nervous system.

Research consistently shows that omega-3s promote cardiovascular health, support cognitive function  , and help maintain a balanced inflammatory response. Because most diets fall short in omega-3s, supplementation is often necessary to reach optimal levels. Ideally, choose a triglyceride form over an ethyl ester form of omega-3’s for superior absorption, utilization, and tolerance.

3. Vitamin D3 with K2

Vitamin D is more than just a vitamin—it’s a hormone that regulates over 1,000 genes. But it works synergistically with vitamin K2, which helps direct calcium into the bones and away from arteries. Together, they enhance skeletal strength, vascular integrity, and immune regulation. Testing your levels ensures you’re supplementing in alignment with your body’s needs.

4. Multi-Strain Probiotic 

Your gut is your second brainand the foundation of immunity. A diverse, high-quality probiotic replenishes beneficial bacteria, supports digestion, reduces systemic inflammation, and enhances the gut-brain axis. Gut dysbiosis (imbalance where there are more bad bacteria than good) can contribute to everything from fatigue and brain fog to skin issues and autoimmune reactivity. Opt for strains like LactobacillusBifidobacterium, and Saccharomyces boulardii backed by clinical data that is dosed at 15 billion cfu or higher.

5. Magnesium (Glycinate, Malate, or Threonate)

Magnesium is required in over 300 enzymatic processes but is one of the most common nutrient deficiencies. Whether it’s for calming the nervous system, improving sleep, or reducing muscle tension, magnesium is foundational. Different forms of magnesium target different systems—glycinate for relaxation, malate for energy, and threonate for brain health and sleep assistance.

Final Thoughts

Infunctional medicine, we don’t guess—we assess. But even before running advanced labs or diving deep into personalized protocols, there’s immense value in starting with foundational nutrition. These core nutrients, when chosen thoughtfully, create the baseline support your body needs to begin healing. Think of them as the roots of a strong tree. When they’re well-nourished, everything thrives.

It’s important to choose practitioner-grade supplements over those found at typical retail stores. Unlike many over-the-counter brands, practitioner-grade products are third-party tested for purity, potency, and bioavailability, while using the highest quality raw materials available. This ensures you’re getting the exact ingredients listed on the label, in forms your body can actually absorb and use. Foundational doesn’t mean basic—it means essential. 

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